BART Trial

This article was published in the NEJM May 2008 (Vol 358 (22) p2319-2331)

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A Comparison of Aprotinin and Lysine Analogues in High-Risk Cardiac Surgery

Summary:

This is a multicentered trial comparing over 2000 high-risk cardiac surgical patients to one of three groups: aprotinin, tranexamic acid or aminocaproic acid. The primary outcome was massive postoperative bleeding. The trial was terminated early because of a higher rate of death in patients receiving aprotinin.

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